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Mechanism of bone incorporation of β-TCP bone substitute in open wedge tibial osteotomy in patients

Paper ID Volume ID Publish Year Pages File Format Full-Text
10992 711 2005 7 PDF Available
Title
Mechanism of bone incorporation of β-TCP bone substitute in open wedge tibial osteotomy in patients
Abstract

A histological study was performed of bone biopsies from 16 patients (17 biopsies) treated with open wedge high tibial osteotomies for medial knee osteoarthritis. The open wedge osteotomies were filled with a wedge of osteoconductive beta tricalcium phosphate (β-TCP) ceramic bone replacement. At the time of removal of the fixation material, core biopsies of the area where the β-TCP was located were taken at different follow-up periods (6–25 months). β-TCP resorption, bone ingrowth and bone remodelling were studied. We hypothesized that the incorporation and remodelling process occurs similarly as in animals.Histology showed a good resorption of the β-TCP with complete incorporation and remodelling into new bone. The different phases as described in animal studies were found. A correlation was found between histological findings and radiological assessment.In conclusion, β-TCP appeared to be a bone replacement material with optimal biocompatibility, resorption characteristics and bone conduction properties for the clinical use.

Keywords
Bone ingrowth; Tricalcium phosphate; Bone remodelling
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Mechanism of bone incorporation of β-TCP bone substitute in open wedge tibial osteotomy in patients
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 33, November 2005, Pages 6713–6719
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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