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Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year

Paper ID Volume ID Publish Year Pages File Format Full-Text
11007 712 1966 10 PDF Available
Title
Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year
Abstract

Pancreatic islet transplantation is one of the most promising strategies for patients suffering from type 1 diabetes mellitus, but several therapeutic immunosuppressive medications must be administered simultaneously to protect transplanted islets in the long-term, and these expose patients to the risk of serious complications. Thus, we developed chemically modified islets with a protective poly(ethylene glycol) (PEG) layer, which reduces immunogenicity by preventing cellular immune reactions. We report here that PEG-based chemical immunomodulation can provide a semi-permanent effective therapy that protects transplanted islets at least for 1 year when accompanied by cyclosporine. Moreover, this combinatorial approach appears to avoid the toxicities associated with immunosuppressive medications because of the reduced amounts of medication required. Also, the conjugated PEG molecules were found to be continuously present at the transplanted islets. However, unmodified islets (control) were completely eliminated within 2 weeks even when CsA was administered. These results strongly suggest that this new combinatorial therapy provides a semi-permanent, effective clinical means of attenuating transplanted islet immunogenicity for a long time, whilst avoiding the toxicities associated with therapeutic levels of immunosuppressants owing to the minimized immunosuppressant.

Keywords
Diabetes; Islet; Cyclosporine; Immunomodulation; PEGylation; Transplantation
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Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 11, April 2007, Pages 1957–1966
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us