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Synthesis, characterization and surface modification of low moduli poly(ether carbonate urethane)ureas for soft tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
1101 76 2009 12 PDF Available
Title
Synthesis, characterization and surface modification of low moduli poly(ether carbonate urethane)ureas for soft tissue engineering
Abstract

Flexible scaffolds are of great interest in engineering functional and mechano-active soft tissues as such scaffolds might allow mechanical stimuli to transfer effectively from the scaffolds to cells during tissue development. Towards this end, we have developed a family of flexible poly(ether carbonate urethane)ureas (PECUUs) with a triblock copolymer poly(trimethylene carbonate)–poly(ethylene oxide)–poly(trimethylene carbonate) (PTMC–PEO–PTMC) or pentablock copolymers PTMC–PEO–PPO–PEO–PTMC (PPO, polypropylene oxide) as soft segments, linked by 1,4-diisocyanatobutane and putrescine. All of the PECUUs had low glass transition temperatures (<−46 °C). The PTMC–PEO–PTMC-containing PECUUs had low tensile strength and breaking strain. Replacing PEO with the similar length PEO–PPO–PEO resulted in highly flexible and soft PECUUs possessing breaking strains of 362–711%, tensile strengths of 8–18 MPa and moduli of 5.5–7.4 MPa at room temperature in air. Under aqueous conditions at 37 °C, these polymers remained flexible while their moduli were decreased to 3.4–4.0 MPa. PECUUs based on PTMC–PEO–PPO–PEO–PTMC were thermosensitive as the water content at 37 °C was lower than that at 4 °C. PECUU using PTMC–PEO–PTMC as a soft segment showed 30% weight loss over 6 weeks in PBS at 37 °C, while that using PTMC–PEO–PPO–PEO–PTMC as a soft segment had weight loss <6%. Degradation products were found to lack cytotoxicity. The mechanical stresses and moduli of PECUUs based on PTMC–PEO–PPO–PEO–PTMC were unchanged during the degradation. To enhance cell adhesion, PECUUs were surface modified with Arg-Gly-Asp-Ser (RGDS). Smooth muscle cell adhesion was 114% of tissue culture polystyrene for unmodified PECUU and >180% for RGDS-modified PECUUs, with cell viability on both surfaces increasing during culture. These low moduli polyurethanes may find applications in engineering cardiovascular or other soft tissues.

Keywords
Poly(trimethylene carbonate); Poly(ether carbonate urethane)urea; Surface modification; Biodegradable
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 8, October 2009, Pages 2901–2912
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us