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Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO2 process

Paper ID Volume ID Publish Year Pages File Format Full-Text
1102 76 2009 7 PDF Available
Title
Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO2 process
Abstract

Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO2 (SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and lower concentration was obtained and applied in the SEDS process. The resulting puerarin nanoparticles were then suspended in PLLA solution and microencapsulated by PLLA in a modified SEDS process, where an ‘injector’ was employed in the particle suspension delivery system. The puerarin nanoparticles exhibited a good spherical shape, a smooth surface and a narrow particle size distribution with a mean particle size of 188 nm. After microencapsulation the puerarin–PLLA microparticles had a mean size of 675 nm, a drug load of 23.6% and an encapsulation efficiency of 39.4%; after a burst release at the first stage, the drug was released in a sustained process. Compared with the parallel study of a co-precipitation process, this microencapsulation process is a much more promising technique to prepare a drug–polymer carrier for a drug delivery system, especially for protein drugs.

Keywords
Biomaterials; Microencapsulation; Poly(l-lactide); Puerarin; Supercritical CO2
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 8, October 2009, Pages 2913–2919
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us