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A scaffold cell seeding method driven by surface acoustic waves

Paper ID Volume ID Publish Year Pages File Format Full-Text
11028 713 2007 7 PDF Available
Title
A scaffold cell seeding method driven by surface acoustic waves
Abstract

Surface acoustic waves (SAW) have been employed to drive a particle suspension into a porous scaffold as a means for cell seeding. Straight, simple interdigital electrode structures were fabricated on lithium niobate to permit the generation of Rayleigh SAW radiation. Fluorescent microscopy was used to investigate the seeding process; the SAW-driven seeding process occurred in approximately 10 s, much quicker than if the scaffold were to be seeded by gravity-driven diffusional processes alone (>30 min). Analysis of high-speed micrographic images demonstrated that the SAW method could also drive particles deeper into the scaffold, thereby significantly improving the uniformity of the particle distribution. The proposed SAW technique therefore offers a promising technology to dramatically improve the speed and uniformity of cell seeding in scaffolds, which might contribute to rapid and uniform tissue regeneration.

Keywords
Surface acoustic wave; Tissue engineering; Rapid cell seeding; Microfluidic actuation
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A scaffold cell seeding method driven by surface acoustic waves
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 28, October 2007, Pages 4098–4104
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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