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Electrodeposition of anchored polypyrrole film on microelectrodes and stimulation of cultured cardiac myocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
11052 715 2007 6 PDF Available
Title
Electrodeposition of anchored polypyrrole film on microelectrodes and stimulation of cultured cardiac myocytes
Abstract

The electrically conducting polymer polypyrrole (PPy) was electrochemically deposited onto Pt microelectrodes on a polyimide (PI) substrate. Pre-modification of the PI surface with a self-assembled monolayer of octadecyltrichlorosilane-induced anisotropic lateral growth of PPy along the PI surface and enhanced adhesive strength of the PPy film. The lateral growth of PPy film around the electrode anchored the whole film to the substrate. External stimulation of cultured cardiac myocytes was carried out using the PPy-coated microelectrode. The myocytes on the microelectrode substrate were electrically conjugated to form a sheet, and showed synchronized beating upon stimulation. The threshold charge for effective stimulation of a 0.8 cm2 sheet of myocytes was around 0.2 μC, roughly corresponding to a membrane depolarization of 250 mV.

Keywords
Cardiomyocyte; Cell culture; Electrical stimulation; Electroactive polymer; Electrochemistry
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Electrodeposition of anchored polypyrrole film on microelectrodes and stimulation of cultured cardiac myocytes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 8, March 2007, Pages 1480–1485
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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