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Subcutaneous xenotransplantation of bovine pancreatic islets

Paper ID Volume ID Publish Year Pages File Format Full-Text
11070 716 2005 8 PDF Available
Title
Subcutaneous xenotransplantation of bovine pancreatic islets
Abstract

Transplantation of pancreatic islets in diabetes is currently limited by the need of immunosuppressive therapy. The present study was designed to test an immunoprotection planar device for subcutaneous xenotransplantation of pancreatic islets in the diabetic rat. We tested three different devices made of polyethersulfone hollow fibers. In all diabetic rats, implantation of islet-containing devices promptly normalized hyperglycemia. In vitro membrane permeability to glucose was correlated with implant function duration. These data confirm that bovine islets contained within devices and implanted subcutaneously remain functional for several days. Strategies to prolong islet function may allow achieving successful long-term islet implantation in this attractive site.

Keywords
Pancreatic islets; Immunoisolation device; Hollow fibers; Subcutaneous site; Xenotransplantation
First Page Preview
Subcutaneous xenotransplantation of bovine pancreatic islets
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 28, October 2005, Pages 5640–5647
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering