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Construction of multi-functional extracellular matrix proteins that promote tube formation of endothelial cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
11088 717 2008 10 PDF Available
Title
Construction of multi-functional extracellular matrix proteins that promote tube formation of endothelial cells
Abstract

We developed artificial extracellular matrix proteins designed to have collagen-binding activity and active functional units that promote network formation of vascular endothelial cells. We engineered a laminin-derived IKVAV sequence, which stimulates capillary network formation of vascular endothelial cells, to incorporate into an elastin-derived structural unit. The designed fusion protein also had a cell-adhesive RGD sequence and a collagen-binding domain derived from fibronectin. The resultant fusion protein could bind to collagen type I and promote angiogenic activity of collagen gel. The collagen-binding domain also had slight angiogenic activity; however, the designed fusion protein also enhanced cellular migration activity. The engineering strategy of designing multi-functional ECM proteins has a possibility for supporting current tissue engineering techniques.

Keywords
Angiogenesis; Collagen; ECM (extracellular matrix); Laminin; Scaffold
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Construction of multi-functional extracellular matrix proteins that promote tube formation of endothelial cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 20, July 2008, Pages 2977–2986
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us