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Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
1114 76 2009 7 PDF Available
Title
Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics
Abstract

This report demonstrates the formation and characterization of sonochemically prepared bovine serum albumin (BSA)–Gemzar (Gemcitabine) microspheres and shows their increased anticancer activity compared to pristine Gemzar. The amount of loaded Gemzar was determined by light absorption measurements. The BSA–Gemzar composite was analyzed and characterized by optical microscopy and scanning electron microscopy. The release kinetics of Gemzar from the proteinaceous microspheres was tested. The BSA–Gemzar composite was examined for its anticancer activity (in vitro) in renal cancer cells (RCC, 786-O cells) using [3H]thymidine incorporation assays. It was found that the influence of the Gemzar-loaded microspheres on the cancer cells was significantly greater than that of an equimolar concentration of pristine Gemzar.

Keywords
BSA microspheres; Sonochemistry; Gemcitabine; Renal cancer 786-O cells; Drug delivery
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Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 8, October 2009, Pages 3031–3037
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us