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Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics

Paper ID Volume ID Publish Year Pages File Format Full-Text
11178 723 2008 9 PDF Available
Title
Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics
Abstract

In this study, the in vivo bone-regenerative capacity and resorption of the porous β-calcium silicate (β-CaSiO3, β-CS) bioactive ceramics were investigated in a rabbit calvarial defect model, and the results were compared with porous β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) bioceramics. The porous β-CS and β-TCP ceramics were implanted in rabbit calvarial defects and the specimens were harvested after 4, 8 and 16 weeks, and evaluated by Micro-CT and histomorphometric analysis. The Micro-CT and histomorphometric analysis showed that the resorption of β-CS was much higher than that of β-TCP. The TRAP-positive multinucleated cells were observed on the surface of β-CS, suggesting a cell-mediated process involved in the degradation of β-CS in vivo. The amount of newly formed bone was also measured and more bone formation was observed with β-CS as compared with β-TCP (p < 0.05). Histological observation demonstrated that newly formed bone tissue grew into the porous β-CS, and a bone-like apatite layer was identified between the bone tissue and β-CS materials. The present studies showed that the porous β-CS ceramics could stimulate bone regeneration and may be used as bioactive and biodegradable materials for hard tissue repair and tissue engineering applications.

Keywords
Calcium silicate; Porous ceramics; Bone regeneration; Resorption; In vivo
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Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 17, June 2008, Pages 2588–2596
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us