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Biodegradable cationic PEG–PEI–PBLG hyperbranched block copolymer: synthesis and micelle characterization

Paper ID Volume ID Publish Year Pages File Format Full-Text
11192 724 2005 9 PDF Available
Title
Biodegradable cationic PEG–PEI–PBLG hyperbranched block copolymer: synthesis and micelle characterization
Abstract

A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)–polyethylenimine–poly(γ-benzyl l-glutamate) (PEG–PEI–PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of γ-benzyl-l-glutamate (BLG–NCA) with PEG–PEI as a macroinitiator. PEG–PEI was firstly prepared by coupling of PEG and PEI using hexamethylene diisocyanate (HMDI). The structural properties of PEG–PEI–PBLG copolymers were confirmed by 1H NMR and GPC. The copolymers were found to be self-assembled in water with critical micelle concentration (CMC) in the range of 0.00368–0.0125 g/l and high hydrophobic micelle core. The micelle size and CMC obviously depended on the hydrophobic block content in the copolymer and the ionic state of the PEI block. The CMC decreased with the increase in the PBLG block content. The decrease of micelle size and the increase of CMC simultaneously occurred with the protonated degree of PEI block by addition of HCl solution. ESEM and Gel retardation assay showed that the cationic micelles had ability to encapsulate plasmid DNA. The copolymer has potential medical applications in drug and gene delivery.

Keywords
Polyethylenimine; Biodegradable; Hyperbranched; Amphiphilic copolymer; Micelle; Complex micelle; Drug delivery
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Biodegradable cationic PEG–PEI–PBLG hyperbranched block copolymer: synthesis and micelle characterization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 20, July 2005, Pages 4209–4217
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us