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Effect of load and temperature on in vitro degradation of poly(glycolide-co-l-lactide) multifilament braids

Paper ID Volume ID Publish Year Pages File Format Full-Text
11206 724 2005 10 PDF Available
Title
Effect of load and temperature on in vitro degradation of poly(glycolide-co-l-lactide) multifilament braids
Abstract

The effects of load and temperature on in vitro degradation behaviors of poly(glycolide-co-l-lactide) 90/10 multifilament braids were investigated in phosphate buffer solution at pH 7.4. The property changes of the braids with time were monitored by tensile test, gel permeation chromatography analysis, and scanning electron microscopy. The interrelationships between material properties, time and experimental conditions were explored. The results showed that the polymer braids gradually lost their strength and molecular weight with the increasing in vitro time. While the load levels applied had no effect on the materials, raising temperatures significantly accelerated the degradation. It was found that for a given tensile breaking strength retention (BSR), the dependence of degradation time on temperature could be illustrated by an Arrhenius-type equation, from which the activation energy could be derived. Further analysis indicated that there are well-defined relationships between molecular weight, BSR and breaking strain retention, and these relationships can be illustrated mathematically. Finally, the surface morphology of the fiber showed visible change during the degradation process.

Keywords
Degradation; In vitro test; Mechanical properties; Molecular weight; Poly(glycolide-co-lactide); Surface analysis
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Effect of load and temperature on in vitro degradation of poly(glycolide-co-l-lactide) multifilament braids
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 20, July 2005, Pages 4327–4336
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us