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The effect of α-tocopherol on the oxidation and free radical decay in irradiated UHMWPE ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
11240 726 2006 8 PDF Available
Title
The effect of α-tocopherol on the oxidation and free radical decay in irradiated UHMWPE ☆
Abstract

We developed a radiation cross-linked ultra-high molecular weight polyethylene (UHMWPE) stabilized with α-tocopherol (Vitamin E) as a bearing material in total joint replacements. The stabilizing effect of α-tocopherol on free radical reactions in UHMWPE is not well understood. We investigated the effect of α-tocopherol on the oxidation and transformation of residual free radicals during real-time aging of α-tocopherol-doped, irradiated UHMWPE (αTPE) and irradiated UHMWPE (control). Samples were aged at 22 °C (room temperature) in air, at 40 °C in air and at 40 °C in water for 7 months. During the first month, αTPE showed some oxidation at the surface, which stayed constant thereafter. Control exhibited substantial oxidation in the subsurface region, which increased with time. The alkyl/allyl free radicals transformed to oxygen centered ones in both materials; this transformation occurred faster in α-TPE. In summary, the real-time oxidation behavior of α-TPE was consistent with that observed using accelerated aging methods. This new UHMWPE is oxidation resistant and is expected to maintain its properties in the long term.

Keywords
Total hip arthroplasty; Highly cross-linked polyethylene; Oxidation resistance; Free radicals; Biomaterials
First Page Preview
The effect of α-tocopherol on the oxidation and free radical decay in irradiated UHMWPE ☆
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 32, November 2006, Pages 5580–5587
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering