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The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
11292 730 2006 8 PDF Available
Title
The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants
Abstract

This study investigates receptor activator NF-κB (RANK), RANK ligand (RANKL) and tumour necrosis factor (TNFα), key factors regulating bone turnover, present in the tissues near peri-prosthetic osteolysis. Tissue was obtained from zones of peri-prosthetic osteolysis from 11 patients undergoing revision of total hip prostheses, analysed preoperatively by high-resolution spiral multislice CT using a metal artefact suppression protocol. Synovial tissue from 10 patients with osteoarthritis undergoing primary hip replacement was used as control tissue. Immunohistochemical analysis of formalin fixed tissue sections demonstrated that RANK, RANKL and TNFα were strongly expressed by large multinucleated cells containing polyethylene wear debris in revision tissues. Control tissue stained weakly for RANK, RANKL and TNFα  . A strong statistical correlation (p<0.02p<0.02) was found between the five parameters, volume of bone loss, polyethylene wear debris, RANK, RANKL and TNFα expression. Importantly, in vitro studies revealed that RANKL and TNFα synergise to increase the volume of bone resorbed, by more than seven fold, when compared to the effect of either cytokine treatment alone. This suggests that the interaction of TNFα and RANKL promotes osteoclast activity associated with polyethylene wear and therapies targeting TNF activity may be useful to treat peri-implant osteolysis.

Keywords
Osteolysis; Osteoclast; Wear debris; Polyethylene; Image analysis
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The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 30, October 2006, Pages 5212–5219
Authors
, , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us