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Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass

Paper ID Volume ID Publish Year Pages File Format Full-Text
11315 731 2006 7 PDF Available
Title
Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass
Abstract

Dense hydroxyapatite (HA) ceramics are useful bone substitutes, but they degrade minimally. One solution is to incorporate degradable materials in the HA. In this study, we manufactured glass-containing HA and investigated whether the degradability and bone-bonding ability of the HA were improved. The glass-containing HA was manufactured from a mixture of HA powder and 1.0 wt% glass powder. The control HA was manufactured from pure HA powder. In vitro degradability was evaluated by soaking in physiological saline, and a rabbit model was used to evaluate in vivo degradability and bone-bonding ability. Detaching tests were performed for all removed samples to quantify bone-bonding ability of each type of HA. The glass-containing HA showed higher degradability than the control HA, both in vitro and in vivo. The detaching failure load of the glass-containing HA was rapidly elevated after implantation and was higher than that of the control HA. Our results suggest that the dissolution of the added glass made the glass-containing HA degradable and that the detaching failure load of the glass-containing HA was elevated by reinforcement of the mechanical locking at the roughened interface. Incorporation of glass additives into HA can be concluded to be a good candidate for producing a bone substitute that can partially degrade and bond to bone firmly and rapidly.

Keywords
Hydroxyapatite; Glass; Mechanical test; Degradation
First Page Preview
Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 27, September 2006, Pages 4738–4744
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering