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Biomineralization of calcium disilicide in porous polycaprolactone scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
11316 731 2006 10 PDF Available
Title
Biomineralization of calcium disilicide in porous polycaprolactone scaffolds
Abstract

The incorporation of CaSi2 grains within a polycaprolactone (PCL) framework results in bioactive and biodegradable scaffolds which may be used in bone tissue regeneration. Porous PCL scaffolds were prepared via a combination of salt-leaching and microemulsion methods. To provide markedly different structural environments for the inorganic phase, calcium disilicide powder was either added to a mixed-composition porogen during a given scaffold preparation, or alternatively added to pre-formed scaffolds. Selective fluorescent labeling, scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) analysis were employed to assess scaffold calcification in vitro. The process of CaSi2/PCL scaffold calcification under zero bias, during which calcium phosphate growth is significantly dependent on the structural degradation of CaSi2 grains, has a similar mechanism as the calcium phosphate growth on bioactive glasses/ceramics. The biomineralization of these scaffolds is initiated solely by the silicide phase and can be accelerated by the degradation of the polymer matrix.

Keywords
Calcium disilicide; Polycaprolactone; Calcification; Tissue engineering scaffold
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 27, September 2006, Pages 4745–4754
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us