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Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
11322 731 2006 11 PDF Available
Title
Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers
Abstract

sNew amorphous amphiphilic triblock copolymers of poly(3-hydroxybutyrate)–poly(ethylene glycol)–poly(3-hydroxybutyrate) (PHB–PEG–PHB) were synthesized using the ring-opening copolymerization of β-butyrolactone monomer. They were characterized by fluorescence, SEM and 1H NMR. These triblock copolymers can form biodegradable nanoparticles with core–shell structure in aqueous solution. Comparing to the poly(ethylene oxide)–PHB—poly(ethylene oxide) (PEO–PHB–PEO) copolymers, these nanoparticles exhibited much smaller critical micelle concentrations and better drug loading properties, which indicated that the nanoparticles were very suitable for delivery carriers of hydrophobic drugs. The drug release profile monitored by fluorescence showed that the release of pyrene from the PHB–PEG–PHB nanoparticles exhibited the second-order exponential decay behavior. The initial biodegradation rate of the PHB–PEG–PHB nanoparticles was related to the enzyme amount, the initial concentrations of nanoparticle dispersions and the PHB block length. The biodegraded products detected by 1H NMR contained 3 HB monomer, dimer and minor trimer, which were safe to the body.

Keywords
Atactic poly(3-hydroxybutyrate); Amphiphilic copolymers; Biodegradable nanoparticle; Biodegradation behavior; Drug carriers
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Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 27, September 2006, Pages 4804–4814
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us