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Finalizing the properties of porous scaffolds of aliphatic polyesters through radiation sterilization

Paper ID Volume ID Publish Year Pages File Format Full-Text
11327 732 2006 13 PDF Available
Title
Finalizing the properties of porous scaffolds of aliphatic polyesters through radiation sterilization
Abstract

Porous scaffolds made of various l,l-lactide (LLA), 1,5-dioxepane-2-one (DXO) and ε-caprolactone (CL) copolymers were sterilized by EB- and γ-irradiation. Differences in the comonomers, composition and the microstructure of the starting materials were used to influence the degradation mechanism and susceptibility towards irradiation and by this means to achieve sterilized scaffolds with predicted end-properties. The chemical changes and the formation of low-molecular-weight products were determined by SEC, 1H nuclear magnetic resonance (NMR), 13C NMR and gas chromatography-mass spectrometry (GC-MS). The degradation mechanism changed from random chain scission to cross-linking depending on the choice of monomers, the copolymer composition and the monomer sequences. Copolymerization of LLA with small amounts of CL or DXO increased the stability compared to that of the LLA homopolymer. Changing DXO to CL in a LLA copolymer also increased the stability. The type of radiation and the microstructure of the copolymer chains determined which of the monomer sequences were more prone to degrade. The most abundant low-molecular-weight product identified after sterilization was DXO monomer. Traces of LLA and CL monomers were also identified. Modification of the copolyester microstructure changed the degradation mechanism and the susceptibility towards irradiation. This allows the use of radiation sterilization to finalize the scaffold properties.

Keywords
Electron beam; Gamma irradiation; Scaffold; Copolymer; Polycaprolactone; Polylactic acid
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Finalizing the properties of porous scaffolds of aliphatic polyesters through radiation sterilization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 31, November 2006, Pages 5335–5347
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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