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The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing

Paper ID Volume ID Publish Year Pages File Format Full-Text
11343 734 2008 9 PDF Available
Title
The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing
Abstract

Poly(vinyl alcohol) (PVA) hydrogels are candidate biomaterials for cartilage resurfacing or interpositional arthroplasty devices requiring high-creep resistance and high water content to maintain lubricity. Annealing of PVA improves creep resistance but also reduces the water content. We hypothesized that maintaining poly(ethylene glycol) (PEG) within PVA during annealing would prevent the collapse of the pores and thus would result in high equilibrium water content (EWC). Our hypothesis tested positive. The PVA hydrogels containing PEG maintained their opacity through annealing and exhibited large pores under confocal imaging while hydrogels not containing PEG turned translucent and no pores were visible after annealing. The EWC of gels annealed with PEG (83±1.0%) was higher than that of the gels processed without PEG (55±4.8). The crystallinity of the former was 8.0±1.7% and the latter was 27.5±8.7%. The hydrogels processed in the presence of PEG exhibited a significantly higher total creep strain (69±3.4%) when compared to the PEG-free hydrogels (17±3.7) under an initial contact stress of 0.45 MPa. EWC appeared to be strongly related to the creep resistance of annealed PVA theta-gels.

Keywords
Polyvinyl alcohol; Hydrogel; Cartilage repair; Polyethylene glycol; Creep resistant; Annealing
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The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 2, January 2008, Pages 141–149
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us