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The haemocompatibility of polyurethane–hyaluronic acid copolymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
11344 734 2008 11 PDF Available
Title
The haemocompatibility of polyurethane–hyaluronic acid copolymers
Abstract

Despite decades of research into haemocompatible biomaterials, there remain surprisingly few materials that can be used in blood-contacting applications. We have synthesized copolymers of polyurethane (PU) with hyaluronic acid (HA) with the goal of creating materials that incorporate an inherently non-thrombogenic, biological component into the bulk polymer structure. HA was incorporated into the polymer backbone as a chain extender during PU synthesis, and the physical and biological properties of the resulting copolymer were directly controlled by the HA content. Increases in HA content led to a linear increase in hydrophilicity (R2=0.993) and corresponding increase in surface energy compared to PU controls. Elastic modulus also increased with HA content (p<0.001), while surface roughness did not significantly differ from PU controls for most PU–HA formulations. Incorporation of HA resulted in negligible platelet adhesion to the PU–HA (p<0.001), representing a 20-fold decrease in platelet adhesion compared to PU. Red blood cell adhesion also decreased with increasing HA content (p<0.001). The PU–HA materials were cytocompatible and supported endothelial cell adhesion and viability. Thus, we have demonstrated the synthesis of a copolymer whose physical and biological properties are easily tailored, and whose potent anti-thrombogenic properties demonstrate its great promise for use in vascular applications.

Keywords
Polyurethane; Hyaluronic acid; Haemocompatibility; Thrombogenicity
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The haemocompatibility of polyurethane–hyaluronic acid copolymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 2, January 2008, Pages 150–160
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us