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Mechanical and histological evaluation of a PMMA-based bone cement modified with γ-methacryloxypropyltrimethoxysilane and calcium acetate

Paper ID Volume ID Publish Year Pages File Format Full-Text
11395 737 2006 7 PDF Available
Title
Mechanical and histological evaluation of a PMMA-based bone cement modified with γ-methacryloxypropyltrimethoxysilane and calcium acetate
Abstract

Polymethylmethacrylate (PMMA) bone cement is widely used for prosthetic fixation in orthopaedic surgery; however, the interface between bone and cement is a weak zone. We developed a bioactive PMMA cement through modification with γ-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. The purpose of this study was to compare the handling, mechanical and histological properties of the modified bone cement with those of the conventional cement. The modified specimens exhibited higher bonding strength between bone and implant. Histological observation and micro-focus X-ray computed tomogram (micro-CT) images showed that the modified cement exhibited osteoconduction, which the conventional PMMA bone cement lacked. The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation.

Keywords
Bioactivity; Bone cement; Mechanical property; In vitro test; In vivo test
First Page Preview
Mechanical and histological evaluation of a PMMA-based bone cement modified with γ-methacryloxypropyltrimethoxysilane and calcium acetate
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 21, July 2006, Pages 3897–3903
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering