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Enzymatic degradation of poly(ether urethane) and poly(carbonate urethane) by cholesterol esterase

Paper ID Volume ID Publish Year Pages File Format Full-Text
11398 737 2006 7 PDF Available
Title
Enzymatic degradation of poly(ether urethane) and poly(carbonate urethane) by cholesterol esterase
Abstract

This study examined the effect of cholesterol esterase (CE) on the degradation of commercial poly(ether urethane) (PEU) and poly(carbonate urethane) (PCU). Unstrained PEU and PCU films were incubated in 400 U/mL CE solution or a buffer control for 36 days. The study used a concentration of cholesterol esterase that was considerably higher than the estimated physiological level in order to accelerate degradation. However, characterization of treated polyurethane films with SEM, attenuated total reflectance Fourier transform infrared (ATR-FTIR) and GPC analysis revealed only a small loss in surface soft segment content. Comparison with implanted PEU and PCU films led to the conclusion that any effect of enzymatic hydrolysis was confined to the immediate surface, and the magnitude of the effect was too small to contribute significantly to in vivo degradation. The study confirmed that oxidation, rather than enzymatic hydrolysis, is the primary mechanism responsible for the observed biodegradation of PEU and PCU. The oxidative H2O2/CoCl2 treatment continues to accurately predict the long-term biostability of polyurethanes.

Keywords
Poly(carbonate urethane); Poly(ether urethane); Biodegradation; Cholesterol esterase; In vivo; In vitro
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Enzymatic degradation of poly(ether urethane) and poly(carbonate urethane) by cholesterol esterase
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 21, July 2006, Pages 3920–3926
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us