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The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial

Paper ID Volume ID Publish Year Pages File Format Full-Text
11420 739 2007 11 PDF Available
Title
The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial
Abstract

This study is the first report of a clinical evaluation of an injectable bone substitute (IBS). This IBS was prepared by suspending biphasic calcium phosphate (BCP) particles with diameters ranging between 80 and 200 μm in a water-soluble cellulose polymer carrier phase. It was used for filling bone defects after tooth extractions in 11 patients. The first objective of the study was to investigate the safety of the filler material. The second objective was to investigate the efficacy of the material for filling human tooth sockets and preventing alveolar bone loss. Radiographic density measurements of the surgical sites gradually increased to those of the surrounding host bone. Three years after surgery, small biopsies of the implanted areas were harvested and analyzed by using micro-computed tomography, non-decalcified histology and histomorphometry. The BCP granules appeared in direct contact with mineralized bone tissue, thereby supporting bone growth. A gradual substitution of the filler by bone tissue was observed thus preserving the height of the alveolar bone crest.

Keywords
Calcium phosphate; Biomaterial; Injectable bone substitute; Human trial; Bone healing
First Page Preview
The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 22, August 2007, Pages 3295–3305
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering