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Use of thermodynamic parameters for design of double-walled microsphere fabrication methods

Paper ID Volume ID Publish Year Pages File Format Full-Text
11454 741 2006 9 PDF Available
Title
Use of thermodynamic parameters for design of double-walled microsphere fabrication methods
Abstract

Double-walled microspheres (DWMS), with drug localized to the particle core, present a promising route for control of drug release rates, for example, by varying the degradation rate or erosion mechanism of the polymer used to form the shell or the thickness of the shell. DWMS are often difficult to fabricate, however. Thermodynamic descriptions for polymer–polymer immiscibility, drug distribution between phases and polymer–solution spreading coefficient provide predictions of appropriate solvents and polymer concentrations for efficiently producing well-formed DWMS. As an example, thermodynamic parameters for a polyphosphoester/poly(d,l-lactide-co-glycolide) (PLG) DWMS system, encapsulating piroxicam, have been calculated and the predictions tested experimentally. Appropriate choices of solvents and initial polymer concentrations resulted in DWMS with the desired polyphosphoester shells and piroxicam located selectively in PLG cores.

Keywords
Microcapsules; Double-walled microspheres; Microencapsulation; Controlled drug release; Piroxicam
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Use of thermodynamic parameters for design of double-walled microsphere fabrication methods
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 14, May 2006, Pages 2898–2906
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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