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Modulation of nano-hydroxyapatite size via formation on chitosan–gelatin network film in situ

Paper ID Volume ID Publish Year Pages File Format Full-Text
11459 742 2007 10 PDF Available
Title
Modulation of nano-hydroxyapatite size via formation on chitosan–gelatin network film in situ
Abstract

Natural bone is actually an inorganic/organic composite mainly make up of nano-hydroxyapatite (Ca10(PO4)6(OH)2, nHA) and collagen fibers. It is most important to form nHA/polymer composites in order to provide good biocompatibility and integration with bone tissue. In this work, nHA was formed in-situ on the surface of chitosan–gelatin (CG) network films in tris-buffer solution containing Ca(NO3)2-Na3PO4. The interaction between CG network film and nHA crystalline were studided using the diffuse reflectance FT-IR (ATR-FTIR), thermal analysis (TGA) and X-ray diffraction analysis (XRD), and the influence the nHA size factors, e.g. the ratio of chitosan (CS) and gelatin (Gel), concentration of calcium ions and reaction temperature, were elucidated by XRD and transmission electron microscope (TEM). Results suggested that carboxyl groups, CO and amino groups play crucial roles for HA formatting on the surface of CG network films and the average size of nHA crystalline decreasing with enhancing Gel content and increase with the increasing calcium and phosphate concentration, and when the reaction temperature below 50 °C the nHA crystalline size is almost fixedness (range from 17.2 to 19.2 nm) but when the temperature arrived at 70 °C it increase to 52.3 nm.

Keywords
Nano-hydroxyapatite; Chitosan; Gelatin; Formation in-situ; Bone tissue engineering
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Modulation of nano-hydroxyapatite size via formation on chitosan–gelatin network film in situ
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 5, February 2007, Pages 781–790
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us