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Biocompatibility of alginate–poly-l-lysine microcapsules for cell therapy ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
11484 744 2006 10 PDF Available
Title
Biocompatibility of alginate–poly-l-lysine microcapsules for cell therapy ☆
Abstract

Cell microencapsulation holds promise for the treatment of many diseases by the continuous delivery of therapeutic products. The biocompatibility of the microcapsules and their biomaterials components is a critical issue for the long-term efficacy of this technology. The objective of this paper is to provide detailed information about the principal factors affecting the biocompatibility of alginates and alginate–poly-l-lysine microcapsules, which are the most frequently employed biomaterials and encapsulation devices for cell immobilization, respectively. Some of these factors include the alginate composition and purification, the selection of the polycation, the interactions between the alginates and the polycation, the microcapsule fabrication process, the uniformity of the devices and the implantation procedure. Improved knowledge will lead to the production of standardized transplantation-grade biomaterials and biocompatible microcapsules.

Keywords
Alginate; Microencapsulation; Biocompatibility; Purification; Poly-l-lysine; Islets of Langerhans
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Biocompatibility of alginate–poly-l-lysine microcapsules for cell therapy ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 20, July 2006, Pages 3691–3700
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us