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The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function

Paper ID Volume ID Publish Year Pages File Format Full-Text
11505 746 2007 12 PDF Available
Title
The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
Abstract

Macrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function.

Keywords
Monocyte; Alveolar macrophage; Tyrosine phosphorylation; Inflammation; RGD; PHSRN; Cytokine
First Page Preview
The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 3, January 2007, Pages 371–382
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering