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The MR tracking of transplanted ATDC5 cells using fluorinated poly-l-lysine-CF3

Paper ID Volume ID Publish Year Pages File Format Full-Text
11511 746 2007 7 PDF Available
Title
The MR tracking of transplanted ATDC5 cells using fluorinated poly-l-lysine-CF3
Abstract

Magnetic resonance (MR) imaging using super-paramagnetic iron oxides (SPIOs) is a powerful tool to monitor transplanted cells in living animals. However, since SPIOs are negative contrast agents it is difficult to track transplanted cells in bone and cartilage that originally display low signals. In this study, we examined the feasibility of tracking with fluorescein isothiocyanate (FITC)-labeled poly-l-lysine-CF3 (PLK-CF3) using mouse ATDC5 cells, a stem cell line of bone and cartilage cells. FITC-labeled PLK-CF3 was easily internalized by ATDC5 cells by adding it into culture medium. No acute or long-term toxicities were seen at less than 160 μg/ml. Labeled cells transplanted into the cranial bone of mice were detected for at least 7 days by MR images. FITC-labeled PLK-CF3 is a useful positive contrast agent for MR tracking in bone and cartilage.

Keywords
Bone; Cartilage; Cell therapy; Molecular imaging; Magnetic resonance; Transplantation
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The MR tracking of transplanted ATDC5 cells using fluorinated poly-l-lysine-CF3
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 3, January 2007, Pages 434–440
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us