fulltext.study @t Gmail

A 5–7 year in vivo study of high-strength hydroxyapatite/poly(l-lactide) composite rods for the internal fixation of bone fractures

Paper ID Volume ID Publish Year Pages File Format Full-Text
11541 747 2006 6 PDF Available
Title
A 5–7 year in vivo study of high-strength hydroxyapatite/poly(l-lactide) composite rods for the internal fixation of bone fractures
Abstract

The biocompatibility and biodegradation of hydroxyapatite (HA)/poly(l-lactide) (PLLA) composite bone implant rods were studied using two types of HA particles as reinforcing fillers, uncalcined-HA (u-HA) or calcined-HA (c-HA). Composite rods of u-HA/PLLA and c-HA/PLLA were implanted into the distal femurs of 25 rabbits. Four of these rabbits lived for more than 5 years after implantation, with one living for 7 years 4 months. Samples were retrieved after the rabbits died naturally and specimens were examined by light microscopy and scanning electron microscopy (SEM). For u-HA/PLLA, the shrinkage of the rods progressed further after 4 years, and some were almost completely resorbed. We could not find traces of the rod in some sections from more than 6 years. Remodeled bone encircled the residual material, and trabecular bone bonded directly to the rod was found toward the center. For u-HA/PLLA 30%, results were similar to u-HA/PLLA 40%, and the cross-sectional area had decreased by 4.0% at over 7 years. Most of the PLLA had been released from the rods. Neither obvious osteolytic nor osteoarthritic changes were found after 4 years.

Keywords
Composite; PLLA; Hydroxyapatite; Biodegradation; Bioresorption; Animal model
First Page Preview
A 5–7 year in vivo study of high-strength hydroxyapatite/poly(l-lactide) composite rods for the internal fixation of bone fractures
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 8, March 2006, Pages 1327–1332
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us