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Mechanical responses of a compliant electrospun poly(l-lactide-co-ε-caprolactone) small-diameter vascular graft

Paper ID Volume ID Publish Year Pages File Format Full-Text
11557 747 2006 9 PDF Available
Title
Mechanical responses of a compliant electrospun poly(l-lactide-co-ε-caprolactone) small-diameter vascular graft
Abstract

To design a “mechano-active” small-diameter artificial vascular graft, a tubular scaffold made of elastomeric poly(l-lactide-co-ε-caprolactone) fabrics at different wall thicknesses was fabricated using an electrospinning (ELSP) technique. The wall thickness of the fabricated tube (inner diameter; approximately 2.3–2.5 mm and wall thickness; 50–340 μm) increased proportionally with ELSP time. The wall thickness dependence of mechanical responses including intraluminal pressure-induced inflation was determined under static and dynamic flow conditions. From the compliance-related parameters (stiffness parameter and diameter compliance) measured under static condition, the smaller the wall thickness, the more compliant the tube. Under dynamic flow condition (1 Hz, maximal/minimal pressure of 90 mmHg/45 mmHg) produced by a custom-designed arterial circulatory system, strain, defined as the relative increase in diameter per pulse, increased with the decrease in wall thickness, which approached that of a native artery. Thus, a mechano-active scaffold that pulsates synchronously by responding to pulsatile flow was prepared using elastomeric PLCL as a base material and an ELSP technique.

Keywords
Poly(l-lactide-co-ε-caprolactone); Electrospinning; Tubular scaffold; Compliance matching; Circulatory apparatus; Strain
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Mechanical responses of a compliant electrospun poly(l-lactide-co-ε-caprolactone) small-diameter vascular graft
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 8, March 2006, Pages 1470–1478
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us