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Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth

Paper ID Volume ID Publish Year Pages File Format Full-Text
11562 747 2006 8 PDF Available
Title
Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth
Abstract

The development of silicone catheters has improved the treatment of hydrocephalus. Unfortunately, the functionality of the catheters used for the treatment of hydrocephalus is compromised by cell obstruction. In this study silicone surfaces coated with biopolymers (heparin and hyaluronan) and self-assembled monolayers (SAM) (octadecyltrichlorosilane—OTS and fluoroalkylsilane—FAS) were employed to investigate the effect of these coatings on astrocyte and choroid plexus cell growth in vitro. Compared to unmodified silicone, FAS surfaces significantly reduced (p<0.05p<0.05) astrocyte proliferation, heparin (p<0.001p<0.001) and hyaluronan (p<0.001p<0.001) surfaces significantly increased astrocyte growth, while no significant difference was observed on OTS surfaces. A similar trend was observed for choroid plexus cell growth on heparin (p<0.05p<0.05) and hyaluronan (p<0.05p<0.05) coatings, however, no significant reduction in cell growth was observed on FAS- or OTS-coated surfaces compared to silicone. Low cell growth may be attributed to hydrophobicity of the surfaces (FAS 112.2±2.6°, OTS 102.2±1.3°). Contact angle measurements confirmed the stability of the hydrophobic and hydrophilic properties of all the coatings on the silicone surfaces for 30 days. Surface roughness did not play an important role on cell growth. Silicone shunts coated with SAMs may be suitable for future clinical applications to improve the treatment of hydrocephalus.

Keywords
Cell growth; Self-assembled monolayer coatings; Polymers; Silicone catheters; Hydrocephalus shunts
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Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 8, March 2006, Pages 1519–1526
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us