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Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion®) in human bones

Paper ID Volume ID Publish Year Pages File Format Full-Text
11565 747 2006 8 PDF Available
Title
Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion®) in human bones
Abstract

Prominent osteoconductive activity and the biodegradable nature of commercially available beta-tricalcium phosphate (β-TCP, OSferion®) have been documented in animal experiments. We analyzed four cases of involving grafted OSferion® in human bone with respect to histological features by routine hematoxylin and eosin staining, silver impregnation, immunohistochemistry and in situ hybridization. OSferion® affords early bioresorption by osteoclasts, vascular invasion of macropores and osteoblastic cell attachment on the surface on the ceramic surface 14 days after grafting. Prominent bone formation and direct bone connection between preexisting bone and OSferion® were evident 28 days after grafting. Nearly the entire TCP surface was covered by lamellar bone; additionally, active osteoblastic lining and attachment of the osteoclast-like giant cells were not observed 72 weeks after grafting. Silver impregnation revealed the presence of collagen fibrils within probable micropores of OSferion®.

Keywords
Bioactive ceramic; Hydroxyapatite; Tricalcium phosphate; Bone graft; Osteoconduction
First Page Preview
Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion®) in human bones
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 8, March 2006, Pages 1542–1549
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering