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The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones

Paper ID Volume ID Publish Year Pages File Format Full-Text
11600 748 2004 8 PDF Available
Title
The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones
Abstract

In order to overcome the continuing infection rate associated with biomaterials, the use of covalently bound furanones as an antibiofilm coating for biomaterials has been investigated. Furanones have previously been shown to inhibit growth of Gram-positive and Gram-negative bacteria. The aim of these studies were to covalently bind furanones to polymers and to test their efficacy for inhibiting biofilm formation of Staphylococcus epidermidis and in vivo infection rate.Two methods of covalent attachment of furanones were used. The first, a co-polymerisation with a styrene polymer, and second, a plasma-1-ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) reaction to produce furanone-coated catheters. Biofilm formation by S. epidermidis in vitro was inhibited by 89% for polystryene–furanone disks and by 78% by furanone-coated catheters (p<0.01). In an in vivo sheep model we found furanones were effective at controlling infection for up to 65 days. Furanones have potential to be used as a coating for biomaterials to control infection caused by S. epidermidis.

Keywords
Antibacterial; Bacteria; Biofilm; Catheter; In vivo test
First Page Preview
The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 20, September 2004, Pages 5023–5030
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering