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Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer

Paper ID Volume ID Publish Year Pages File Format Full-Text
11654 751 2006 10 PDF Available
Title
Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer
Abstract

A series of self-crosslinkable and biodegradable polymers, poly(caprolactone fumarate) (PCLF), poly(ethylene glycol fumarate) (PEGF), and their copolymer PEGF-co-PCLF, has been developed for tissue engineering applications using a novel synthesis method. The current method employs potassium carbonate (K2CO3), other than the previously reported triethylamine, as the proton scavenger. The new synthetic route is more convenient and less time-consuming to carry out, and the synthesized polymers have a much lighter color, which renders them more suitable for self-crosslinking via photo-initiation. This group of polymers are essentially copolymers of fumaryl chloride, which contains double bonds for in situ crosslinking, with poly(ε-caprolactone) (PCL) or/and poly(ethylene glycol) (PEG) that has a flexible chain to facilitate self-crosslinking. Both PCLF and PEGF, and their amphiphilic copolymer PEGF-co-PCLF could be self-crosslinked or photocrosslinked to produce scaffolds without the use of a crosslinking agent. Our results suggest that these polymers are potentially useful as injectable, self-crosslinkable, and photo-crosslinkable materials for diverse tissue engineering applications.

Keywords
Polymerization; Polycaprolactone; Polyethylene oxide; Cross-linking; Amphiphilic polymer network
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Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 6, February 2006, Pages 832–841
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us