fulltext.study @t Gmail

Interaction of B50 rat hippocampal cells with stain-etched porous silicon

Paper ID Volume ID Publish Year Pages File Format Full-Text
11655 751 2006 5 PDF Available
Title
Interaction of B50 rat hippocampal cells with stain-etched porous silicon
Abstract

We present a scanning electron microscopy study of interaction of porous silicon prepared by stain etching with rat hippocampal neurons (B50, immortalised line). Porous Si has been prepared by stain etching both from crystalline and polycrystalline substrates. Two types of patterns have been examined: (i) 100 μm square pads separated by 100 μm of untreated space and (ii) 30 μm and 100 μm stripes separated by 300 μm of untreated surface. In all cases cells show clear preference in adhesion to porous Si over untreated surface. We observe a much closer attachment of the cell to the surface of porous Si than has been anticipated before with the gap between a cell and porous surface of no more than 20 nm. This study demonstrates the influence of surface topology on proliferation of a neuron network, thus suggesting that a degree of control over cell growth pattern can be achieved using porous material alone. We show that the network pattern on porous Si is influenced by a single neuron response to the surface nature and topology.

Keywords
SEM; Microstructure; Neural network; Neural cell; B50; Surface topography
First Page Preview
Interaction of B50 rat hippocampal cells with stain-etched porous silicon
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 6, February 2006, Pages 842–846
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering