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Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
11662 751 2006 12 PDF Available
Title
Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering
Abstract

Bone is a complex porous composite structure with specific characteristics such as viscoelasticity and anisotropy, both in morphology and mechanical properties. Bone defects are regularly filled with artificial tissue grafts, which should ideally have properties similar to those of natural bone. Open cell composite foams made of bioresorbable poly(l-lactic acid) (PLA) and ceramic fillers, hydroxyapatite (HA) or β-tricalcium phosphate (β-TCP), were processed by supercritical CO2 foaming. Their internal 3D-structure was then analysed by micro-computed tomography (μCT), which evidenced anisotropy in morphology with pores oriented in the foaming direction. Furthermore compressive tests demonstrated anisotropy in mechanical behaviour, with an axial modulus up to 1.5 times greater than the transverse modulus. Composite scaffolds also showed viscoelastic behaviour with increased modulus for higher strain rates. Such scaffolds prepared by gas foaming of polymer composite materials therefore possess suitable architecture and properties for bone tissue engineering applications.

Keywords
Composite; Scaffold; Compression; MicroCT; Anisotropy
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Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 6, February 2006, Pages 905–916
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us