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UHMWPE and vitamin E bioactivity: An emerging perspective ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
11681 753 2006 5 PDF Available
Title
UHMWPE and vitamin E bioactivity: An emerging perspective ☆
Abstract

Ultra-high molecular weight polyethylene (UHMWPE) is a semicrystalline biomaterial widely used in the components for articular prosthesis for its excellent mechanical qualities.Two major problems limit the UHMWPE prosthesis life—wearing and delamination, both phenomena being mainly due to chemical oxidation of polymer. Wearing causes the release of generated particulate that triggers a macrophage reaction leading to chronic inflammation and osteolysis, while delamination, due to the mechanical stress, macroscopically alters the surfaces. The most diffused method to reduce wearing is UHMWPE molecular cross-linking by high-energy irradiation followed by melting that also reduces polymer fatigue strength. For this reason, the use of vitamin E (α-tocopherol), as an anti-oxidative and biocompatible additive for normal and cross-linked UHMWPE, has been suggested as an alternative method to improve polymer wearing resistance without altering its mechanical strength. This paper describes briefly the rationale of vitamin E as UHMWPE additive and its possible use as an emerging perspective in the orthopaedic field.

Keywords
UHMWPE; Vitamin E; Oxidation; Cross-linking
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UHMWPE and vitamin E bioactivity: An emerging perspective ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 16, June 2006, Pages 3039–3043
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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