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Ethoxysilane-capped PEO–PPO–PEO triblocks: a new family of reverse thermo-responsive polymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
11708 754 2004 8 PDF Available
Title
Ethoxysilane-capped PEO–PPO–PEO triblocks: a new family of reverse thermo-responsive polymers
Abstract

New reverse thermo-responsive polymers systems combining reverse thermal gelation behavior and a gradual increase in the mechanical properties, were created by crosslinking ethoxysilane-capped poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblocks in aqueous solutions at physiological conditions. Pluronic F127 (PEO99–PPO67–PEO99) was functionalized with (3-isocyanatopropyl) triethoxysilane (IPTS) by reacting its terminal hydroxyl groups with the isocyanate. The silane-capped PEO–PPO–PEO triblock was characterized by 1H-NMR, GPC, FT-IR and DSC and the rheological behavior of its aqueous solutions were studied. The silane-containing triblock retained the reverse thermo-responsive characteristics displayed by the original Pluronic. Over time, the ethoxysilane groups hydrolysed and created silanol moieties that subsequently condensated, crosslinking the material and generating hydrogels that exhibited gradually increasing mechanical properties. It was found that the higher the pH, the faster the process and the higher the viscosity levels attained. Finally, the ability of these gels to perform as matrices for drug delivery was exemplified by releasing metronidazole and methylene blue. Findings showed that while a 30% F127 gel at 37°C delivered all the drug within less than 3 days, F127di-IPTS gels completed the process at a much slower rate (up to 15 days).

Keywords
Injectable biomaterials; Reverse thermo-sensitive polymers; Ethoxysilane-capped PEO–PPO–PEO; Rheological behavior; Controlled release
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Ethoxysilane-capped PEO–PPO–PEO triblocks: a new family of reverse thermo-responsive polymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 14, June 2004, Pages 2851–2858
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us