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Molecular basis of cell–biomaterial interaction: Insights gained from transcriptomic and proteomic studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
11717 755 2006 12 PDF Available
Title
Molecular basis of cell–biomaterial interaction: Insights gained from transcriptomic and proteomic studies
Abstract

With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell–biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials.

Keywords
Biocompatibility; Transcriptomics; DNA microarrays; Proteomics; Mass spectrometry; Cell interaction
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Molecular basis of cell–biomaterial interaction: Insights gained from transcriptomic and proteomic studies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 35, December 2006, Pages 5871–5882
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us