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Platinum nanowire nanoelectrode array for the fabrication of biosensors

Paper ID Volume ID Publish Year Pages File Format Full-Text
11725 755 2006 7 PDF Available
Title
Platinum nanowire nanoelectrode array for the fabrication of biosensors
Abstract

Platinum nanowire arrays can be grown by electrodeposition in polycarbonate membrane, with the average diameter of the nanowires about 250 nm and the height about 2 μm. The nanowire array prepared by the proposed method can be considered as nanoelectrode array (NEA) with nanoelectrode density of 5×108 cm−2. While the NEA can improve the signal-to-noise ratio and decrease the detection limit, the high surface area of the platinum NEA circumvents the problem of conventional platinum electrodes associated with the limited electroactive site. The platinum NEA can direct response to hydrogen peroxide at low potential of 0 V with wide linear range (1×10−7–6×10−2 m) and sensitivity 50 times larger than that of the conventional platinum electrode. With the absorption of glucose oxidase onto the ordered NEA surface, the spatially patterned glucose oxidase improves greatly the resulting biosensor. The biosensor can achieve interference free determination of glucose with wide linear range (10−6–3×10−2 m). The sensitivity of the glucose biosensor is one-fifth of the sensitivity toward hydrogen peroxide, indicating high efficiency of signal transduction. The biosensor was used to determine glucose in real blood samples, and the glucose contents determined by the present biosensor were in agreement with the results of existing method.

Keywords
Biosensor; Enzyme; Platinum nanowire; Polycarbonate membrane; Nanoelectrode array
First Page Preview
Platinum nanowire nanoelectrode array for the fabrication of biosensors
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 35, December 2006, Pages 5944–5950
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering