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Analysis of degradation data of poly(l-lactide–co-l,d-lactide) and poly(l-lactide) obtained at elevated and physiological temperatures using mathematical models

Paper ID Volume ID Publish Year Pages File Format Full-Text
1176 78 2010 8 PDF Available
Title
Analysis of degradation data of poly(l-lactide–co-l,d-lactide) and poly(l-lactide) obtained at elevated and physiological temperatures using mathematical models
Abstract

The degradation of resorbable polymeric devices often takes months to years. Accelerated testing at elevated temperatures is an attractive but controversial technique. The purposes of this paper include: (a) to provide a summary of the mathematical models required to analyse accelerated degradation data and to indicate the pitfalls of using these models; (b) to improve the model previously developed by Han and Pan; (c) to provide a simple version of the model of Han and Pan with an analytical solution that is convenient to use; (d) to demonstrate the application of the improved model in two different poly(lactic acid) systems. It is shown that the simple analytical relations between molecular weight and degradation time widely used in the literature can lead to inadequate conclusions. In more general situations the rate equations are only part of a complete degradation model. Together with previous works in the literature, our study calls for care in using the accelerated testing technique.

Keywords
Biodegradation; Resorbable polymers; Modelling; Accelerated testing; Data analysis
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Analysis of degradation data of poly(l-lactide–co-l,d-lactide) and poly(l-lactide) obtained at elevated and physiological temperatures using mathematical models
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 10, October 2010, Pages 3882–3889
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us