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Generation of porous microcellular 85/15 poly (dl-lactide-co-glycolide) foams for biomedical applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
11763 757 2004 7 PDF Available
Title
Generation of porous microcellular 85/15 poly (dl-lactide-co-glycolide) foams for biomedical applications
Abstract

Porous 85/15 poly (dl-lactide-co-glycolide) or PLGA foams were produced by the pressure quench method using supercritical CO2 as the blowing agent. The rate of CO2 uptake and CO2 equilibrium concentration in PLGA at different processing conditions were studied by performing sorption experiments. The effects of saturation pressure and temperature on average cell size and relative density of the resulting foams were also studied. The time required to approach equilibrium exhibited a minimum with increasing saturation pressure. The diffusion coefficient and equilibrium concentration of CO2 in PLGA increased with an increasing pressure in an approximately linear relationship. Porous PLGA foams were generated with relative densities ranging from 0.107 to 0.232. Foams showed evidence of interconnected cells with porosities as high as 89%. The pore size ranged from 30 to 100 μm.

Keywords
Microcellular foams; PLGA; Porous polymers; Tissue engineering; Scaffold; Biodegradable
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Generation of porous microcellular 85/15 poly (dl-lactide-co-glycolide) foams for biomedical applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 13, June 2004, Pages 2611–2617
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us