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Intramedullary fixation of femoral cortical osteotomies with interlocked biodegradable self-reinforced poly-96l/4d-lactide (SR-PLA96) nails

Paper ID Volume ID Publish Year Pages File Format Full-Text
11769 757 2004 9 PDF Available
Title
Intramedullary fixation of femoral cortical osteotomies with interlocked biodegradable self-reinforced poly-96l/4d-lactide (SR-PLA96) nails
Abstract

Femoral diaphyseal osteotomies of adult sheep were fixed with intramedullary (IM) biodegradable self-reinforced poly-96L/4D-lactide (SR-PLA96) nails (∅ 10.66–10.78 mm×195–199 mm) that were interlocked with four ∅ 1.5 mm metallic Kirschner (K) wires. Hollow IM nails used in the pilot study resulted in implant failure and only two of these sheep were followed long term (18 months and 3 years). In the main study, solid nails were used and this resulted in consolidation in 5/6 cases and in one non-union due to failure of both proximal K wires at 3 weeks. Sheep in the main study were followed for 6 and 12 months. Femurs were studied radiographically, microradiographically, histologically and by oxytetracycline labelling. Good bone healing was achieved and histology showed only a mild tissue reaction to the implant at 6–18 months. At 3 years, the implant had almost degraded and numerous foamy macrophages were ingesting the disintegrated material. No accumulations of lymphocytes implying an immunological inflammatory reaction were seen. This investigation demonstrated that absorbable SR-PLA96 IM nails can be used together with interlocking metallic K wires in fixation of simple cortical osteotomies in large animals weighing up to 63 kg. The long-term biocompatibility should be studied in a larger population.

Keywords
Polylactic acid; Self-reinforced; Cortical; Bone healing; PLA96
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Intramedullary fixation of femoral cortical osteotomies with interlocked biodegradable self-reinforced poly-96l/4d-lactide (SR-PLA96) nails
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 13, June 2004, Pages 2669–2677
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us