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A new in vivo screening model for posterior spinal bone formation: Comparison of ten calcium phosphate ceramic material treatments

Paper ID Volume ID Publish Year Pages File Format Full-Text
11793 759 2006 13 PDF Available
Title
A new in vivo screening model for posterior spinal bone formation: Comparison of ten calcium phosphate ceramic material treatments
Abstract

This study presents a new screening model for evaluating the influence of multiple conditions on the initial process of bone formation in the posterior lumbar spine of a large animal. This model uses cages designed for placement on the decorticated transverse process of the goat lumbar spine. Five conduction channels per cage, each be defined by a different material treatment, are open to both the underlying bone and overlying soft tissue. The model was validated in ten adult Dutch milk goats, with each animal implanted with two cages containing a total of ten calcium phosphate material treatments according to a randomized complete block design. The ten calcium phosphate ceramic materials were created through a combination of material chemistry (BCP, TCP, HA), sintering temperature (low, medium, high), calcination and surface roughness treatments. To monitor the bone formation over time, fluorochrome markers were administered at 3, 5 and 7 weeks and the animals were sacrificed at 9 weeks after implantation. Bone formation in the conduction channels was investigated by histology and histomorphometry of non-decalcified sections using traditional light and epifluorescent microscopy. According to both observed and measured bone formation parameters, materials were ranked in order of increasing magnitude as follows: low sintering temperature BCP (rough and smooth)≈medium sintering temperature BCP≈TCP>calcined low sintering temperature HA>non-calcined low sintering temperature HA>high sintering temperature BCP (rough and smooth)>high sintering temperature HA (calcined and non-calcined). These results agree closely with those obtained in previous studies of osteoconduction and bioactivity of ceramics thereby validating the screening model presented in this study.

Keywords
Animal model; Bioactivity; Calcium phosphate; Osteoconduction; Osteogenesis
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A new in vivo screening model for posterior spinal bone formation: Comparison of ten calcium phosphate ceramic material treatments
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 3, January 2006, Pages 302–314
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us