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The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation

Paper ID Volume ID Publish Year Pages File Format Full-Text
11802 759 2006 9 PDF Available
Title
The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation
Abstract

The suitability of chitosan-based hydrogels as scaffolds for the encapsulation of intervertebral disc (IVD) cells and the accumulation of a functional extracellular matrix mimicking that of the nucleus pulposus (NP) was investigated. The specific hypothesis under study was that the cationic chitosan would form an ideal environment in which large quantities of newly synthesized anionic proteoglycan could be entrapped. Indeed, all the formulations of cell-seeded chitosan hydrogels, studied under in vitro culture conditions, showed that the majority of proteoglycan produced by encapsulated NP cells was retained within the gel rather than released into the culture medium. This was not always the case when annulus fibrosus cells were encapsulated, as unlike the nucleus cells the annulus cells often did not survive when cultured in chitosan. The results support the concept that chitosan may be a suitable scaffold for cell-based supplementation to help restore the function of the NP during the early stages of IVD degeneration.

Keywords
Chitin/chitosan; Cell encapsulation; Hydrogel; Intervertebral disc; Nucleus pulposus; Proteoglycan
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The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 3, January 2006, Pages 388–396
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us