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Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone

Paper ID Volume ID Publish Year Pages File Format Full-Text
11829 760 2006 7 PDF Available
Title
Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone
Abstract

The bone-bonding behaviors of various biomaterials have been extensively investigated. However, the precise mechanisms of bone bonding have not yet been clarified, and the differences in interfacial behaviors of biomaterial bonding with cancellous bone and cortical bone have not yet been understood. In this study, strontium-containing hydroxyapatite (Sr-HA) cement, in which 10% calcium ions were substituted by strontium, was performed in a rabbit hip replacement model. Six months later, the morphology and chemical composition of interfaces between Sr-HA cement with cancellous bone and cortical bone were evaluated by field emission scanning electron microscopy (FESEM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Remarkable differences between these two interfaces were suggested both in morphology and chemical compositions. An apatite layer was found between Sr-HA cement and cancellous bone with a thickness of about 70 μm. However, only a very thin interface (about 1 μm) was formed with cortical bone. As for the cancellous bone/cement interface, high ions intensity of Ca, P, Sr, Na, and O were confirmed by FESEM-EDX and ToF-SIMS. Differences in morphology and chemical component between these two interfaces provided convincing evidences for the proposed dissolution–precipitation coupling mechanism in the formation of biological apatite.

Keywords
Strontium-containing hydroxyapatite bone cement; Bone-bonding behaviors; Interface; Mechanism; Chemical composition
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Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 29, October 2006, Pages 5127–5133
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us