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In vitro effects of Ag+ on planktonic and adhered cells of fluconazole-resistant and susceptible strains of Candida albicans, C. glabrata and C. krusei

Paper ID Volume ID Publish Year Pages File Format Full-Text
11844 761 2006 6 PDF Available
Title
In vitro effects of Ag+ on planktonic and adhered cells of fluconazole-resistant and susceptible strains of Candida albicans, C. glabrata and C. krusei
Abstract

Planktonic and attached cells of strains of Candida albicans, C. glabrata and C. krusei with varied susceptibilities to fluconazole (FCZ) were compared for their relative susceptibilities to Ag+ via cell recovery and flow cytometric analyses. All strains lost membrane permeability and were non-recoverable upon culture after 1 h exposure in morpholino-ethanesulfonic acid (MES) buffer fortified with ⩽2.0 μg/ml Ag+. Cells attached to silicone over a 2-h period demonstrated enhanced tolerance to FCZ and to a lesser degree to Ag+. Minimal inhibitory concentrations of Ag+ in defined media increased in the order C. glabrata, C. krusei, C. albicans. Susceptibilities to Ag+ did not correlate with tolerance or resistance to FCZ.

Keywords
Candida albicans; C. glabrata; C. krusei; Fluconazole tolerance; Silver
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In vitro effects of Ag+ on planktonic and adhered cells of fluconazole-resistant and susceptible strains of Candida albicans, C. glabrata and C. krusei
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 13, May 2006, Pages 2755–2760
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us