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Alginate–whey protein granular microspheres as oral delivery vehicles for bioactive compounds

Paper ID Volume ID Publish Year Pages File Format Full-Text
11899 765 2006 9 PDF Available
Title
Alginate–whey protein granular microspheres as oral delivery vehicles for bioactive compounds
Abstract

Alginate (AL)–whey protein isolate (WPI) microspheres of varied WPI/AL ratio, particle diameter and concentration of polymer bead forming solution (CAL+WPI) were prepared in order to develop a biocompatible vehicle for oral administration of bioactive compounds. Microscopy revealed a special matrix/granular structure for microspheres with a WPI/AL ratio of 8:2, 100 μm diameter and CAL+WPI of 5% (AL–WPI A2), featuring WPI granules 3–10 μm in diameter homogeneously distributed within an AL spherical matrix. The compound release properties of these microspheres were investigated in simulated gastric and intestinal fluids (SGF and SIF). They demonstrated the desirable property of retarding riboflavin release in SGF and underwent alginate matrix erosion together with liberation of WPI granules in SIF, followed by complete release of the riboflavin. Riboflavin release in SGF and in SIF without pancreatin followed the Higuchi diffusion model while release in SIF in the presence of pancreatin was attributed to WPI granule degradation.

Keywords
Microspheres; Alginate; Whey protein; Bioactive compounds; Oral administration
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Alginate–whey protein granular microspheres as oral delivery vehicles for bioactive compounds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 26, September 2006, Pages 4646–4654
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us