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Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium

Paper ID Volume ID Publish Year Pages File Format Full-Text
11906 766 2006 12 PDF Available
Title
Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium
Abstract

In order to improve orthopedic implant performance, the objective of this in vitro study was to synthesize nanocrystalline hydroxyapatite (HA) powders to coat titanium. HA was synthesized through a wet chemical process. The precipitated powders were either sintered at 1100 °C for 1 h in order to produce UltraCap HA (or microcrystalline size HA) or were treated hydrothermally at 200 °C for 20 h to produce nanocrystalline HA. Some of the UltraCap and nanocrystalline HA powders were doped with yttrium (Y) since previous studies demonstrated that Y-doped HA in bulk improved osteoblast (or bone-forming cell) function over undoped HA. The original HA particles were characterized using X-ray diffraction (XRD), inductively coupled plasma–atomic emission spectroscopy (ICP–AES), BET, a laser particle size analyzer, and scanning electron microscopy (SEM). These powders were then deposited onto titanium by a novel room-temperature process, called IonTite™. The properties of the resulting HA-coatings on titanium were compared to respective properties of the original HA powders. The results showed that the chemical and physical properties of the original HA powders were retained when coated on titanium by IonTite™, as determined by XRD, SEM, and atomic force microscopy (AFM) analysis. More importantly, results showed increased osteoblast adhesion on the nanocrystalline HA IonTite™ coatings compared to traditionally used plasma-sprayed HA coatings. Results also demonstrated greater amounts of calcium deposition by osteoblasts cultured on Y-doped nanocrystalline HA coatings compared to either UltraCap IonTite™ coatings or plasma-sprayed HA coatings. These results encourage further studies on nanocrystalline IonTite™ HA coatings on titanium for improved orthopedic applications.

Keywords
Nanocrystalline; Y-doped hydroxyapatite; Plasma-spray; Osteoblast; Orthopedic; Nanotechnology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 11, April 2006, Pages 2358–2369
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us