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Migration stability of α-tocopherol in irradiated UHMWPE

Paper ID Volume ID Publish Year Pages File Format Full-Text
11914 766 2006 6 PDF Available
Title
Migration stability of α-tocopherol in irradiated UHMWPE
Abstract

The oxidation resistance of irradiated ultra-high molecular weight polyethylene (UHMWPE) components used in total joint arthroplasty can be improved by adding α-tocopherol (vitamin E) through diffusion. To ensure long-term oxidative stability, a minimum α-tocopherol concentration needs to be maintained throughout these components. Migration of α-tocopherol out of the components is one mechanism that could compromise long-term oxidative stability. We hypothesized that α-tocopherol could elute out during standard implant fabrication steps such as cleaning as well as during in vivo use. We doped 85 kGy irradiated UHMWPE with α-tocopherol at 120 °C and homogenized at 120 °C. We determined the extent of elution of α-tocopherol or its effect on oxidative stability following cleaning in isopropyl alcohol (IPA) and following 5 million cycles (MC) of simulated normal gait in bovine serum. There was no significant elution of α-tocopherol in repeated and prolonged cleaning in IPA as measured by average surface and bulk α-tocopherol concentrations. There was no change in the oxidative stability following 5 MC of hip simulator testing, indicating minimal elution during simulated normal gait.

Keywords
Antioxidant; Vitamin E; Highly cross-linked polyethylene; Joint replacement; Degradation; Oxidation
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Migration stability of α-tocopherol in irradiated UHMWPE
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 11, April 2006, Pages 2434–2439
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us